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DC Field | Value | Language |
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dc.contributor.author | Rickaby, Barbara Ashley | - |
dc.date.accessioned | 2015-05-27T15:44:12Z | - |
dc.date.available | 2015-05-27T15:44:12Z | - |
dc.date.issued | 2015-05-27 | - |
dc.identifier.uri | https://zone.biblio.laurentian.ca/dspace/handle/10219/2399 | - |
dc.description.abstract | The high incidence of Campylobacter jejuni-associated diarrhea, increase in the frequency of drug resistance in clinical isolates, and the recent association of C. jejuni infections and Guillain-Barré syndrome has heightened the need to develop effective anti-Campylobacter vaccines. Due to the risk of auto-immunity, vaccination using inactivated whole-cells or attenuated cells cannot be considered. Subunit vaccines however are a viable alternative and have been shown to be effective against similar pathogens. The main goal of this research is to test efficacy of the catalase A (KatA) protein as vaccine candidate against this pathogen. It was determined that KatA co-fractionates with both the soluble and insoluble cell fractions and a balanced IgG1/IgG2a response could be produced against it following immunization in mice. It was demonstrated that these antibodies can mediate complement-specific bactericidal activity and reduced adhesion and invasion of human epithelial (Caco-2) cells by C. jejuni using established in vitro assays. | en_CA |
dc.language.iso | en_US | en_CA |
dc.publisher | Laurentian University of Sudbury | en_CA |
dc.subject | Campylobacter jejuni | en_CA |
dc.subject | catalase | en_CA |
dc.subject | functional antibodies | en_CA |
dc.subject | KatA | en_CA |
dc.subject | vaccine, | en_CA |
dc.title | Intramuscular immunization of mice with KatA (catalase) generates functional antibodies against Campylobacter jejuni invasion of gut epithelial cells in vitro | en_CA |
dc.type | Thesis | en_CA |
dc.description.degree | Master's Theses | en_CA |
dc.publisher.grantor | Laurentian University of Sudbury | en_CA |
Appears in Collections: | Biology - Master's Theses Master's Theses |
Files in This Item:
File | Description | Size | Format | |
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M Sc Thesis B Rickaby 2015_1.pdf | 815.82 kB | Adobe PDF | View/Open |
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