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https://zone.biblio.laurentian.ca/handle/10219/3940
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DC Field | Value | Language |
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dc.contributor.author | Butt, Shahnawaz | - |
dc.date.accessioned | 2022-09-16T13:43:45Z | - |
dc.date.available | 2022-09-16T13:43:45Z | - |
dc.date.issued | 2021-09-02 | - |
dc.identifier.uri | https://zone.biblio.laurentian.ca/handle/10219/3940 | - |
dc.description.abstract | Enterotoxigenic Escherichia coli (ETEC) produces the heat-stable enterotoxin b (STb), which is responsible for secretory diarrhea in humans and animals. STb disrupts intestinal fluid homeostasis, epithelial barrier function, and promotes apoptosis. Glucagon-like peptide-2 (GLP2) is an intestinotrophic growth hormone secreted by enteroendocrine L-cells which enhances cellular proliferation, epithelial barrier function, and inhibits apoptosis. As many similarities are clear between GLP-2 production and secretion pathways and STb cell signaling mechanisms, this study aims to investigate the effects STb has on the physiology of in-vitro L-cells and the secretion of GLP-2. Enteroendocrine cells which secreted the highest amounts of growth hormone were found to be more resistant to STb intoxication. STb was found to enhance the secretion of GLP-2, potentially due to similar cellular mechanisms of hormone production and secretion and STb cell signaling. GLP-2 was found to inhibit the toxigenic effects of STb. Future work will elucidate the mechanism of this interaction. This work will support the use of GLP-2 therapies in enterotoxigenic related diseases. | en_US |
dc.language.iso | en | en_US |
dc.subject | Escherichia coli | en_US |
dc.subject | ETEC | en_US |
dc.subject | toxins | en_US |
dc.subject | proteins | en_US |
dc.subject | hormones | en_US |
dc.subject | glucagon-like peptide-2 | en_US |
dc.subject | hormone secretion | en_US |
dc.subject | enterotoxins | en_US |
dc.subject | gastrointestinal | en_US |
dc.subject | enterotoxigenic | en_US |
dc.subject | enteroendocrine | en_US |
dc.title | A gut reaction: effects of an e. coli-produced toxin on gut hormone regulation and gut physiology | en_US |
dc.type | Thesis | en_US |
dc.description.degree | Master of Science (MSc) in Biology | en_US |
dc.publisher.grantor | Laurentian University of Sudbury | en_US |
Appears in Collections: | Biology - Master's Theses |
Files in This Item:
File | Description | Size | Format | |
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Shahn Butt Thesis Final Submission.pdf | 1.72 MB | Adobe PDF | View/Open |
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