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dc.contributor.authorHillebrand, Rebecka-
dc.description.abstractInstrument operation and degree of carryover produced by the Biotage® RapidTrace® and the Gilson® GX-271 ASPEC™ solid-phase extraction liquid handler systems was compared. Samples of animal blood, human blood, and human serum were spiked with a high concentration mix of 10 drugs commonly encountered in forensic casework. They were extracted preceding three blank samples of corresponding matrix on both instruments and all samples were subsequently screened on an Ultra Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC-QTOF-MS) instrument to evaluate differences in drug response values. It was found that the GX-271 ASPEC™ instrument produced lower overall drug responses in blank samples and faster time to extinction of drug responses, thereby demonstrating improved control of carryover. This instrument also showed an improvement over the RapidTrace® in overall performance and ease of operation and is therefore recommended as a beneficial replacement.en_CA
dc.subjectForensic toxicologyen_CA
dc.subjectsolid-phase extractionen_CA
dc.subjectGX-271 ASPEC™en_CA
dc.titleComparison of the Biotage® RapidTrace® and Gilson® GX-271 ASPEC™ solid phase extraction automated liquid handler systems for drug screening applications in forensic caseworken_CA
dc.description.degreeSubmitted in Partial Fulfilment of the Course FORS 4205en_CA
dc.publisher.grantorLaurentian University of Sudburyen_CA
Appears in Collections:Forensic Science - Internships

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