Please use this identifier to cite or link to this item: https://zone.biblio.laurentian.ca/handle/10219/2779
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHillebrand, Rebecka-
dc.date.accessioned2017-07-27T13:26:21Z-
dc.date.available2017-07-27T13:26:21Z-
dc.date.issued2017-07-26-
dc.identifier.urihttps://zone.biblio.laurentian.ca/handle/10219/2779-
dc.description.abstractInstrument operation and degree of carryover produced by the Biotage® RapidTrace® and the Gilson® GX-271 ASPEC™ solid-phase extraction liquid handler systems was compared. Samples of animal blood, human blood, and human serum were spiked with a high concentration mix of 10 drugs commonly encountered in forensic casework. They were extracted preceding three blank samples of corresponding matrix on both instruments and all samples were subsequently screened on an Ultra Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC-QTOF-MS) instrument to evaluate differences in drug response values. It was found that the GX-271 ASPEC™ instrument produced lower overall drug responses in blank samples and faster time to extinction of drug responses, thereby demonstrating improved control of carryover. This instrument also showed an improvement over the RapidTrace® in overall performance and ease of operation and is therefore recommended as a beneficial replacement.en_CA
dc.language.isoenen_CA
dc.subjectForensic toxicologyen_CA
dc.subjectsolid-phase extractionen_CA
dc.subjectblooden_CA
dc.subjectserumen_CA
dc.subjectRapidTrace®en_CA
dc.subjectGX-271 ASPEC™en_CA
dc.subjectUPLC-QTOF-MSen_CA
dc.subjectcarryoveren_CA
dc.titleComparison of the Biotage® RapidTrace® and Gilson® GX-271 ASPEC™ solid phase extraction automated liquid handler systems for drug screening applications in forensic caseworken_CA
dc.typeOtheren_CA
dc.description.degreeSubmitted in Partial Fulfilment of the Course FORS 4205en_CA
dc.publisher.grantorLaurentian University of Sudburyen_CA
Appears in Collections:Internships

Files in This Item:
File Description SizeFormat 
R Hillebrand Internship 2017.pdf1.04 MBAdobe PDFThumbnail
View/Open


Items in LU|ZONE|UL are protected by copyright, with all rights reserved, unless otherwise indicated.