Please use this identifier to cite or link to this item: https://zone.biblio.laurentian.ca/handle/10219/2530
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dc.contributor.authorFraleigh, Nya L.-
dc.date.accessioned2016-03-09T15:40:42Z-
dc.date.available2016-03-09T15:40:42Z-
dc.date.issued2015-01-26-
dc.identifier.urihttps://zone.biblio.laurentian.ca/dspace/handle/10219/2530-
dc.description.abstractThe incidence of allergic disease has risen dramatically over the last century. This increase cannot simply be attributed to genetics, and so environmental contributions to allergic disease must be considered. Airborne particulate matter is recognized as a contributing factor in the initiation and exacerbation of allergic respiratory diseases due to its ability to act as an adjuvant and irritant. Particulate matter is heterogeneous in composition, and different components contribute to its adjuvant effects, including metals. This thesis investigates whether metals contained in Sudbury Particulate Matter (SPaM) are potential immunomodulators. We investigated the ability of metals in SPaM to influence inflammation both in vivo and in vitro. We demonstrate that the metals are able to alter the inflammatory profile after physiologically relevant exposure levels, suggesting that some of the metals present in SPaM are immunomodulatory in nature and may influence allergic disease. Key Wordsen_CA
dc.language.isoenen_CA
dc.subjectParticulate matteren_CA
dc.subjectInhalation intoleranceen_CA
dc.subjectSudbury Particulate Matteren_CA
dc.subjectNickelen_CA
dc.subjectCopperen_CA
dc.subjectEstrogenen_CA
dc.titleInvestigating the immunomodulatory potential of metals present in Sudbury Particulate Matter (SPaM)en_CA
dc.typeThesisen_CA
dc.description.degreeMaster of Science (MSc) in Biology-
dc.publisher.grantorLaurentian University of Sudbury-
Appears in Collections:Master's Theses
Master's Theses

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